Skip to main content

Table 3 AUC data - ITT set for (A) sore throat relief (TOTPAR) from baseline to 2 hours post dose, (B) change from baseline in difficulty swallowing from baseline to 2 hours post dose and (C) throat numbness measurements from 1 to 120 minutes post dose

From: A multicentre, randomised, double-blind, single-dose study assessing the efficacy of AMC/DCBA Warm lozenge or AMC/DCBA Cool lozenge in the relief of acute sore throat

 

AMC/DCBA

Warm lozenge

AMC/DCBA

Cool lozenge

Unflavoured,

non-medicated

lozenge

(A) Sore throat relief (TOTPAR)

   

N

77

74

74

Mean ± SD

1.70 ± 1.19

2.06 ± 1.30

0.94 ± 1.04

LS meana

1.74

2.10

0.98

Parameter estimates

LS meanb

95% CI

P-value

AMC/DCBA Warm lozenge - unflavoured, non­medicated lozenge

0.76

0.38,1.14

0.0001 ***

AMC/DCBA Cool lozenge - unflavoured, non­medicated lozenge

1.12

0.73,1.50

<0.0001 ***

(B) Difficulty in swallowing

   

N

77

74

74

Mean ± SD

-13.4 ± 14.4

-19.2 ± 14.6

-7.7 ± 13.2

LS meanc

-13.5

-19.3

-7.5

Parameter estimates

LS meand

95% CI

P-value

AMC/DCBA Warm lozenge - unflavoured, non-medicated lozenge

-5.9

-10.4,-1.5

0.009 ***

AMC/DCBA Cool lozenge - unflavoured, non-medicated lozenge

-11.7

-16.2,-7.2

<0.0001 ***

(C) Throat numbness

   

N

77

74

74

Mean ± SD

1.86 ± 0.83

2.18 ± 0.86

1.54 ± 0.72

LS meana

1.80

2.12

1.48

Parameter estimates

LS meanb

95% CI

P-value

AMC/DCBA Warm lozenge - unflavoured, non-medicated lozenge

0.32

0.06,0.58

0.017 *

AMC/DCBA Cool lozenge - unflavoured, non-medicated lozenge

0.64

0.38,0.90

<0.0001 ***

  1. a Estimated from ANCOVA model with factors for treatment and centre and a covariate for baseline throat soreness.
  2. b A positive difference favours the first treatment against second treatment.
  3. c Estimated from ANCOVA model with factors for treatment and centre and covariates for baseline throat soreness and baseline score for difficulty in swallowing.
  4. d A negative difference favours the first treatment against second treatment.
  5. *** Significantly different compared with the unflavoured, non-medicated lozenge at the 0.1% level.
  6. CI, confidence interval; LS, least-squares; SD, standard deviation.
  7. Sore throat relief measured on a 7-point scale where 0 = No relief, 1 = Slight relief, 2 = Mild relief, 3 = Moderate relief, 4 = Considerable relief, 5 = Almost complete relief, 6 = Complete relief.
  8. Difficulty in swallowing measured on 100 mm VAS where 0 mm = Not difficult, 100 mm = Very difficult.
  9. Throat numbness measured on a 5-point scale where 1 = None, 2 = Mild, 3 = Moderate, 4 = Considerable, 5 = Complete.