Skip to main content

Table 4 Subgroup analysis of the intervention effect on the percentage of days adherence to prescribed medication

From: An explanatory randomised controlled trial of a nurse-led, consultation-based intervention to support patients with adherence to taking glucose lowering medication for type 2 diabetes

Sub-group variable

Sub-group category (L = Low or H = High)

N per sub group

Intervention arm

Standard care arm

Intervention- Control (SE)*

Difference (H-L) (95% C.I.)

P interaction

HbA1c % (mmol/mol)

7.5 – 7.9 (58-63)

85

80.4 (24.5)

62.6 (34.2)

17.7 (6.4)

  
 

8.0 - 12.4 (64-112)

108

74.8 (27.7)

72.8 (27.8)

2.0 (5.3)

-15.8 (-32.9, 1.2)

0.07

Age (years)

37 – 64

94

75.0 (25.61)

72.3 (27.3)

2.7 (5.6)

  
 

65 and over

100

80.0 (27.1)

66.4 (33.2)

13.5 (6.0)

10.8 (-5.4, 27.2)

0.19

Total number of medications

0 – 5

89

80.2 (23.3)

73.0 (27.0)

7.2 (5.3)

  
 

6 and over

105

75.1 (28.5)

65 .2 (33.7)

10.0 (6.1)

2.8 (-13.5, 19.1)

0.74

Self reported adherence at baseline

0-23

102

75.0 (26.4)

70.9 (27.2)

4.1 (5.5)

  
 

24 or 25

70

85.9 (21.3)

68.0 (33.9)

17.9 (6.8)

13.8 (-3.2, 30.0)

0.11

Prior randomisation to medication monitoring device

No

102

76.6 (28.7)

71.0 (29.3)

5.6 (5.8)

  
 

Yes

92

78.2 (23.7)

66.65 (32.6)

11.6 (5.9)

6.0 (-10.5, 22.7)

0.48

Gender

Male

127

77.0 (28.3)

66.4 (31.5)

10.6 (5.3)

  
 

Female

67

78.0 (22.9)

74.8 (28.8)

3.3 (6.4)

-7.3 (-24.3, 9.6)

0.39

  1. Effect estimates, confidence intervals and p-values from non-parametric bootstrap percentile method (50,000 replications).
  2. * Estimated intervention effects are positive within each subgroup.