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Table 2 Assessment of AD usefulness

From: Evidence of prescription of antidepressants for non-psychiatric conditions in primary care: an analysis of guidelines and systematic reviews

  -Neuropathic pain (neuralgia and painful polyneuropathy), diabetic painful neuropathy, central neuropathic pain, migraine, tension-type headaches, fibromyalgia
Useful (1) -Urinary stress incontinence, premature ejaculation
n = 15 -Prevention of depression after stroke, emotionalism after stroke -Smoking cessation
-Premenstrual syndrome, hot flashes/drug therapy, hot flashes during menopause
-Irritable bowel syndrome
Possibly useful (2) -Post herpetic neuralgia, trigeminal neuralgia
n = 5 -Agitation in dementia, motor recovery after ischemic stroke
-Overactive bladder syndrome
No proof of benefit (3) - Tension-type headaches with drug abuse, sciatica, Parkinson’s disease, sleep disorders
n = 15 - pruritus
- Asthenia- fatigue-chronic fatigue syndrome, cancer-related fatigue, depression in physically ill people
- Unexplained complaints, somatoform disorders, treatment refusal, patient compliance, weight loss in adults with type 2 diabetes
Proof of no benefit (4) -HIV related neuropathy, phantom limb pain, burning mouth syndrome, non-specific low back pain, restless legs syndrome
n = 9 -Other urinary incontinence conditions, erectile dysfunction -Alcoholism /
alcohol misuse
  -Musculoskeletal symptoms (5)
  1. (1) Recommended with evidence level mentioned or recent meta-analysis. (2) Mentioned without level of evidence, or second line treatment, or only RCTs. (3) Not enough or no data, apart from psychiatric condition. (4) No benefit mentioned in RCTs or reviews. (5) See fibromyalgia in Table 3.