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Table 1 Dosing regimens and duration in trials of statins

From: Statins in hypercholesterolaemia: A dose-specific meta-analysis of lipid changes in randomised, double blind trials

 

Number

Doses used (mg/day)

 

Statin

Trials

Patients

Fixed

Titrated

Double blind treatment (weeks)

Atorvastatin

5

1334

10

10–20

12–52

Cerivastatin

5

2316

0.025

0.05–0.3

12–52

   

0.05

  
   

0.1

  
   

0.2

  
   

0.3

  
   

0.4

  
   

0.8

  

Fluvastatin

9

1209

20

20–40

12–52

   

40

40–80

 
   

80

  

Lovastatin

13

8561

40

20–40

12–48

   

80

20–80

104

    

40–80

 

Pravastatin

44

11811

10

10–20

12–26

   

20

20–40

156–260

   

40

40–80

 

Rosuvastatin

4

1005

5

5–80

12 fixed (additional 40 wk dose titration in 2 trials)

   

10

10–80

 

Simvastatin

31

17168

2.5

5–10

12–120

   

5

5–20

156–260

   

10

5–40

 
   

20

10–40

 
   

40

20–40

 
   

80

  
  1. Note 1: Explanation of number of trials and patients. For atorvastatin, five trials compared atorvastatin with placebo or another drug. The number of patients given atorvastatin in was 1334. Comparator treatments are listed without patient numbers. Note 2: Several statins may have been assessed in a single trial. For example, one study compared rosuvastatin with simvastatin and pravastatin. Information from the trial is added to the rows for rosuvastatin, simvastatin and pravastatin.