Skip to main content

Advertisement

Table 3 Effect of statin according to initial concentration of total cholesterol. Most commonly used dose in the trials.

From: Statins in hypercholesterolaemia: A dose-specific meta-analysis of lipid changes in randomised, double blind trials

     Weighted mean change from baseline
Number of trials Number of patients Initial [TC]* Weighted mean initial [TC]* Absolute Percent
Cerivastatin 0.4 mg      
2 527 All combined 7.0 -1.7 -25
1 332 6.0–6.9 6.8 -1.8 -26
1 195 7.0–7.9 7.2 -1.7 -24
Fluvastatin 40 mg      
5 376 All combined 7.6 -1.3 -17
1 25 6.0–6.9 6.4 -0.8 -12
3 287 7.0–7.9 7.4 -1.3 -18
1 40 9.0–9.9 9.1 -1.6 -17
Lovastatin 40 mg      
7 3743 All combined 6.8 -1.5 -23
2 3436 6.0–6.9 6.7 -1.5 -23
1 211 7.0–7.9 7.0 -1.4 -20
1 96 9.0–9.9 9.6 -2.1 -22
Pravastatin 40 mg      
17 6635 All combined 6.5 -1.3 -20
2 261 5.0–5.9 5.4 -1.1 -20
8 2315 6.0–6.9 6.2 -1.1 -18
6 3866 7.0–7.9 7.1 -1.4 -20
1 193 9.0–9.9 9.2 -2.1 -23
Simvastatin 40 mg      
4 10952 All combined 5.7 -1.5 -26
1 10269 5.0–5.9 5.6 -1.5 -26
1 41 6.0–6.9 6.7 -1.8 -27
1 206 7.0–7.9 7.0 -1.9 -28
1 436 8.0–8.9 8.1 -2.5 -31
  1. * Initial [TC]: mean concentration of total cholesterol, in mmol/L, at baseline