Skip to main content

Advertisement

Table 4 Factors associated with excessive polypharmacy (≥10 substances); results from the multivariable generalized linear mixed model

From: Polypharmacy in older patients with chronic diseases: a cross-sectional analysis of factors associated with excessive polypharmacy

  Univariable Multivariable
Factors OR (95% CI) p OR (95% CI) p
Sex (female vs male) 1.18 (1.03–1.35) 0.0189 1.03 (0.89–1.19) 0.6718
Age group (≥85 vs < 85) 0.96 (0.82–1.13) 0.6388 0.83 (0.70–0.99) 0.0328
Educational level (low vs medium/high/missing) 0.94 (0.81–1.10) 0.4440 0.95 (0.80–1.13) 0.5506
Frailty (frail/terminally ill vs managing well/vulnerable/missing) 1.83 (1.57–2.13) <.0001 1.45 (1.22–1.71) <.0001
BMI (≥30 vs < 30) 1.34 (1.16–1.54) <.0001 1.18 (1.02–1.38) 0.0303
Smoker (smoker vs non-smoker/ex-smoker/missing) 0.83 (0.59–1.16) 0.2763 0.85 (0.60–1.21) 0.3579
Research centre (Austria vs Germany 1) 0.69 (0.52–0.93) 0.0139 0.97 (0.72–1.31) 0.8519
Research centre (Italy vs Germany 1) 0.58 (0.44–0.75) <.0001 0.90 (0.67–1.21) 0.4950
Research centre (UK vs Germany 1) 0.92 (0.70–1.22) 0.5561 1.71 (1.27–2.30) 0.0004
Research centre (Germany 2 vs Germany1) 0.71 (0.54–0.94) 0.0150 0.74 (0.56–0.97) 0.0303
Number of diagnoses (> 8 vs ≤8) 2.70 (2.32–3.14) <.0001 2.64 (2.24–3.11) <.0001
Physical health composite score (≤36.635 vs > 36.636) 1.83 (1.58–2.11) <.0001 1.47 (1.26–1.72) <.0001
Mental health composite score (≤48.7 vs > 48.8) 1.53 (1.33–1.76) <.0001 1.36 (1.17–1.59) <.0001
  1. Legend: Germany 1 = Rostock, Germany 2 = Witten